Sentence examples for modulate the phenotype from inspiring English sources
The purpose of this work was to investigate if a coculture system of human mesenchymal stem cells (hMSC) with endothelial cells (human umbilical vein endothelial cells, HUVEC) could modulate the phenotype and proliferation of harvested MSCs.
A high negative correlation predicts that the agents could modulate the phenotype, but do not indicate their potency in doing so.
Instead, we speculate that changes in mitochondrial Zn pools may perform regulatory functions to modulate the phenotype of the highly differentiated secretory epithelium during lactation.
In addition to clearly pathogenic mutations, polymorphic genetic variants may also modulate the phenotype (Luoma et al., 2005).
Second, we aimed to determine the underlying mechanism by which monocyte-platelet interactions modulate the phenotype and function of monocytes.
Thus, it is highly likely that the infiltrated Th1 cells modulate the phenotype of TAMs in oral premalignant lesions.
Our study suggests that topography may modulate the phenotypes of macrophages and foam cells in the context of foreign body response.
On the other hand, it did not segregate with the clinical phenotype because it occurred in two patients with different clinical findings and its association with rRNA deletion (in P3) or tRNA variant (in P9) might be modulating the phenotype of these two patients.
Because Tregs can be induced locally by DCs with an immature phenotype that produce IL-10 [29], [30], [30], it is possible that TBHsp70 modulates the phenotype of DCs, inducing a regulatory response, and IL-10 production by DCs, leading to the recruitment and/or induction of Tregs.
Regardless of the experimental technology used, the screening strategies aim to quantify the extent to which a mutation in one gene modulates the phenotype (or fitness) associated with altering the second gene, either by explicitly measuring or analytically comparing the observed fitness of double-mutants to those of single-mutants.
This observation highlights the importance of genetics and environmental variations in modulating the phenotype in humans.
