Sentence examples for modulate the metastatic from inspiring English sources

This study was specifically designed to identify the metastasis relevant microRNAs in colorectal cancer and characterize microRNAs that modulate the metastatic phenotype.

Conversely, some miRNAs that are secreted from stromal cells can modulate the metastatic ability of DTCs.

We have recently reported a novel function for carbonyl reductase (CR), namely, its ability to modulate the metastatic potential of malignant mouse cells.

Support for this model comes from studies demonstrating that methylation inhibitors can modulate the metastatic capacity of cell lines [ 24- 28].

IRF8, which was strongly upregulated in SL4-CXCL16 cells (Table  1), has been reported to sensitize Fas-mediated apoptosis in soft tissue sarcoma cells and to modulate the metastatic phenotype of CRC by regulating Fas expression [ 37, 38].

The tumor microenvironment is a critical regulator of cancer progression [ 60] and integrin-mediated interactions between tumor cells and the extracellular matrix (ECM) modulate the metastatic potential of tumor cells [ 63].

Of these, there is increasing evidence that macrophages play an important role in modulating the metastatic capacity of the tumor.

70 These results provide new insight into the mechanisms of allyl sulfides on modulating the metastatic potency of human cancer cells.

Several studies have shown that the adhesion of cancer cells to E-selectin initiates a reverse signaling in the cancer cells, which raises the possibility that this signaling modulates the metastatic potential of cancer cells [ 20- 22].

Furthermore, the interaction of cancer cells with their stromal microenvironment overcomes the physiological barrier function of stromal cells and may also modulate the invasive and metastatic phenotype of the cancer cells, as well as angiogenesis [ 30].

The importance of hypoxia-induced genes in promoting metastatic tumour cell invasion and migration is well-established [ 12- 17], and emerging evidence indicates that secreted hypoxia-induced proteins such as lysyl oxidase (LOX) [ 18] can modulate the microenvironment within distant metastatic target organs to promote metastatic tumour growth [ 19].