The research described ranged from large population studies, to clinical trials using dietary and other interventions to modulate the microbiota, and mechanistic studies investigating bacterial effects at the cellular and molecular level on the gut-associated immune system, the gut barrier and the gut mucosa.
However, whereas individual differences in neuroticism are thought to modulate the effect of stress on mental health, the mechanistic link between stress, neuroticism and amygdala responsivity is unknown.
Further, alterations in pyrophosphate binding are thought to aid in the modulation of prenyl chain orientation within the active site and most likely modulate the fate of the early intermediates along prescribed mechanistic pathways 30).
* Claim 7 tries to couch the findings in a mechanistic setting, claiming that TF levels modulate the effect of DNA sequence variation.
Thus, from the mechanistic point, trehalose octasulfate employs a multitarget strategy to modulate the activity of multiple components of thrombus formation, suggesting a dual mechanism of action.
miRNA studies provide mechanistic insights into genetic regulations that may modulate the risk of ASD.
Based on data from mechanistic studies, the ability of micronutrients to modulate the toxicity of metals is indisputable.
In mechanistic studies, we demonstrate for the first time that EpCAM expression can modulate the c-Jun N-terminal kinase (JNK /activator protein 1 (AP-1) signal transduction pathway and target genes.
Furthermore, our computational approaches suggest a framework to bin compounds into mechanistic classes, which holds particular relevance to future efforts to use polypharmacy to modulate the immune response by suggesting combinations that might target the maximal breadth of inflammatory pathways.
These findings reveal the molecular architecture of the AKAP-Lbc transduction complex and provide a mechanistic explanation of how upstream signaling pathways can be integrated within the AKAP-Lbc transduction complex to precisely modulate the activation of Rho.
