Sentence examples for modulate the manner from inspiring English sources

Together, the available data points to the need for development of dual therapeutic strategies that modulate microglia activation to change not only the way microglia interact with the peripheral immune system, but also to modulate the manner in which microglia respond to encounters with α-syn.

Biochemical studies in transfected cells show that Otop1 modulates the manner in which cells handle intracellular calcium in response to purinergic stimuli [ 11].

Dopaminergic projections to the entorhinal cortex are likely to play an important role in modulating the manner in which the entorhinal cortex contributes to sensory integration and mnemonic processing.

Thus, lysosomal Ca 2+ signaling may modulate plasticity in the manner required at all stages of multiple membrane fusion events that are dependent on Ca 2+ for the effective formation of the SNARE complexes.

However, the involvement of a LeuT-like S2 binding site and any mechanistic role that an S2-bound substrate might have in modulating DAT function in the manner described for LeuT, remain open questions that are examined here in the context of the allosteric mechanism responsible for conformational transitions in DAT.

Prebiotics are nondigestible food ingredients that are fermented in the gut and modulate the microbiota in a manner beneficial to the host [ 59– 61].

Acting either in a paracrine manner to modulate the activity of surrounding cells or in an autocrine fashion, cytokines perform a wide variety of functions.

It is now well known that aberrations in the epigenome can contribute to a variety of diseases, and thus discovery of small molecules that modulate the epigenome in a specific manner is an important undertaking.

These receptors work in a coordinated manner to modulate the responses of neurons to neurotrophins.

Consistent with these results, an imbalance of DAF-21 levels between different tissues could also modulate the HSR in a global manner.

Hypoxia is known to modulate the p53 pathway, in a manner dependent or not of hypoxia induction factor-1, the severity and the duration of hypoxia influence p53 protein level and activity, in a cell-specific manner.