Sentence examples for modulate the malignant from inspiring English sources

In this study we sought to identify genes that modulate the malignant phenotype of bladder cancer.

Moreover, infiltrating B cells might modulate the malignant potential of tumor cells via the production of certain chemokines or cytokines.

CMV can modulate the malignant phenotype in GBMs, therefore DC vaccines pulsed with CMV antigens can be used to reduce GBM malignancy.

In addition, delineation of how chemokine ligands and receptors modulate the malignant phenotype will provide novel insights into the pathogenesis of lung carcinoma.

The presence of catalytic domains characteristic of classic PKC- β and atypical PKC- ι within PKC- ζ-PrC provides a potential mechanism for this PRKCZ variant to modulate the malignant prostatic phenotype out-with normal cell-regulatory control.

Inclusion of catalytic domains characteristically expressed in classic PKC- β and atypical PKC- ι- enzymes provides novel evidence that anomalous variants of PK enzymes are powerful agents potentially able to independently modulate the malignant prostatic phenotype out-with normal regulatory mechanisms.

Oncogenic EGFRvIII in glioblastoma cells induces FOSL1 [ 41], and it modulates the malignant features of glioma cells, so it was suggested as target for therapeutic interventions against malignant gliomas [ 42].

Inhibition of miRNA-27a suppressed the growth, colony formation, and migration of pancreatic cancer cells, and further data indicated that miRNA-27a played an oncogenic role and modulated the malignant, biological behavior of pancreatic cancer cells by targeting SPRY2 [ 42].

It is also a limitation that the findings presented in this study may not be uniformly true for a wide variety of cancer cells, considering a divergent function of TGF- β1 in modulating the malignant phenotype of cancer cells (Desruisseau et al, 1996; Tuxhorn et al, 2002).

Peinado et al. have recently shown that cancer-derived exosomes modulate the crosstalk between malignant cells and the bone marrow (BM) microenvironment.

ZMYND domain-containing proteins define a protein family whose members associate with molecules such as co-repressors to regulate transcription and may modulate the process of malignant transformation.