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Since TRAX appears to regulate the cellular localization of translin, it is possible that TRAX may similarly modulate the localization of other cellular proteins.
Differential phosphorylation of phosphatidylinositol results in phosphoinositides, which may function as precursors of second messengers or to modulate the localization, conformation, and activity of bound proteins.
Levels of cellular lipid second messengers, such as the phosphoinositide PtdIns5P, change in response to a variety of stresses and can modulate the localization, conformation and activity of a number of intracellular proteins.
In addition to its directs effects on components of chromatin, PARP-1 may also modulate the localization and activity of a broad array of histone-modifying and nucleosome remodeling enzymes.
Altogether, the findings indicate that ITSN is a key plasma membrane scaffold able to modulate the localization and activity of TGFβ receptors family and to participate in the spatio-temporal regulation of TGFβ signaling necessary for endothelial cell and lung tissue homeostasis.
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Therefore, in the present experiments, the presence or absence of CD4+ T cell help was modulating the localization of CD8+ T cells into the mesenteric nodes.
Overproduction of ClpX increased cell length and modulated the localization of FtsZ at midcell sites; however, intracellular FtsZ levels were unaffected.
We then analyzed the manner in which the Ras-MAPK pathway modulated the localization of GLR-1.
The heterogeneity in organelles and membrane leaflets is, as previously mentioned, critical in modulating the localization of membrane-bound proteins and their functional properties.
One study has indicated that modulating the localization of ERKs in the nucleus is responsible for colorectal cancer cell apoptosis [ 42].
Such heterogeneity in organelles and membrane leaflets is critical in modulating the localization of membrane-bound proteins and their functional properties.
More suggestions(15)
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modulate the growth
modulate the process
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modulate the secretion
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