Among the inter-organ communication factors, muscle-secreted myokines can modulate the function and survival of pancreatic beta-cells.
The substance has also been shown to modulate the function of certain types of immune cells (e.g., T cells).
Additionally, the generation of microexons is an AS event that can modulate the function of interaction domains of proteins involved in neurogenesis8.
"With this chemical probe discovery, we could look for pinches of magic dust that would modulate the function of the protein," she says.
Drugs which modulate the function of these neurotransmitter systems are widely used for the treatment of many major neurological and psychiatric conditions such as major depression and schizophrenia.
Small molecules have been used successfully to modulate the function of the bacterial ribosome, viral RNAs and riboswitches.
SREC-I was also shown to modulate the function of Toll like receptors with essential roles in innate immunity.
Many questions remain unanswered, but the results have begun to suggest ways in which emotional structures in the brain might modulate the function of normal sensory and motor neural circuits.
Gawrisch and co-workers23,24 co-workers23,24ate NMR, have proposed that DHA-containing phospholipids causing certain degree of membrane elasolidstates that could modulate the fuNMRion of integral receptor proteins suchave rhodoproposed
Building on these key discoveries, a team of scientists at Vertex, led by Paul Negulescu, initiated research in 1998 to identify compounds that modulate the function of the CFTR protein.
Modularly assembled combinatorial libraries are often used to identify ligands that bind to and modulate the function of a protein or a nucleic acid.
