Sentence examples for modulate the flexibility from inspiring English sources

Thus, these Arf/Arl residues (as well as the corresponding glycine brace residues) may help modulate the flexibility of the guanine binding loop and consequently its nucleotide affinity in response to upstream regulatory signals.

Residues corresponding to an N-[VI] motif that is conserved within Arf/Arl GTPases may play a role in the interswitch toggle characteristic of the Arf family, whereas other, co-conserved residues may modulate the flexibility of the guanine binding loop.

In addition, Ackerley et al. have shown that p38α phosphorylates NF-M and NF-H on their side-arm domains in cortical neurons, thereby modulating the flexibility and stability of the cytoskeleton [29], [54].

Unlike the effect of the H-bonds across the loop, significant spectral shifts arise from modulating the flexibility of the CXXCH arm, in particular the δ(Ca S1 C PyrI internal coordinate from Cys12, and the torsional and bending modes of His16.

Since glutamine is more hydrophilic than arginine, the amino acid substitution may affect the relative position of the two functional domains by modulating the flexibility of the linker connecting them [ 57].

These results collectively indicate that microenvironmental factors can uniquely modify the phenotype of differentiated recruited monocytes inducing marked changes in mRNA levels and also in miRNA expression and kinetics that may modulate the remarkable flexibility of monocyte responses to specific environmental cues.

The linker between the GEF and CC domains might help to modulate the conformational flexibility and/or the relative conformations of the two domains and thus plays a minor role in the autoinhibition.

Furthermore, modulating the substrate flexibility could possibly enable the application of existing neural recording and stimulating arrays to more reliably probe spaces and expand our understanding of signaling and modulation in the cochlea and beyond.

The observations of this work show that the energy factor of trilinear SDOF systems subjected to near-fault earthquake ground motions is appreciably influenced by the hysteretic parameters in multiple yielding stages, and engineers have sufficient flexibility to modulate the seismic energy balance of the system by adjusting these influential parameters.

This raises the interesting possibility that both time and reward value modulate the firing of serotonergic neurons, increasing the flexibility of the serotonergic signal.

Comparison of this structure with that of other peptide receptors suggests that endogenous peptide ligands with a high degree of conformational flexibility may bind and modulate the receptors via a similar two-site binding mechanism.