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Moreover, GRP activates nuclear factor kappa B-dependent pathway to modulate the expressions of interleukin-8 and vascular endothelial growth factor in prostate cancer cells [27].
Yet it is unclear which molecular aberrations modulate the expressions of the intermediate regulators.
Genetic and epigenetic alterations on DNAs modulate the expressions and activities of key regulators such as transcription factors and microRNAs.
Exercise has recently been shown to modulate the expressions of genes involved in the Wnt signaling [ 150].
The SSTR1 was found to modulate the expressions of many important genes involved in multiple cellular process, including cell cycle, apoptosis, migration and invasion.
Three subtypes of PPARs, PPAR α, PPAR γ, and PPAR δ, have been shown to modulate the expressions of various genes to exert bioactivity [ 5].
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The transcription factors in turn modulate the expression of down-stream genes resulting in metabolic modulations.
Twist1 2 also modulate the expression of E protein-dependent genes by sequestrating E-protein modulators.
In addition, polymorphisms in the promoter region of GABRB3 might modulate the expression of this gene.
Four synthetic 5′-untranslated regions were designed for atoB using UTR Designer to modulate the expression level of the gene.
It becomes highly intriguing how spermidine and spermine could modulate the expression of T3SS genes.
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