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The elevated amounts of acid and glucans modulate the establishment of cariogenic organisms within tightly adherent biofilms known as dental plaque.
Astrocytes modulate the establishment and maintenance of synaptic contacts through the release of soluble factors such as cholesterol [19] or thrombospondins [20], or by direct physical interaction with neuronal cells [10] [13], [21].
Importantly, periconceptual nutritional influences may modulate the establishment of these epigenetic changes at metastable epialleles.
Importantly, periconceptual nutritional influences may modulate the establishment of epigenetic changes, such as DNA methylation at MEs.
Binding of MeCP2 to hemimodified hmCpG/mCpG compared to either symmetrically modified DNA is a distinct state of MeCP2 binding that in turn may differentially modulate the establishment and/or maintenance of repressive chromatin structures.
Their existence is well documented in the mouse since the pioneering studies on the agouti viable yellow (A vy ) locus, and, in this model, maternal diet has been shown to modulate the establishment of the epigenetic marks (reviewed in [ 38]).
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More recently, Truman et al. [ 27] and Attaran et al. [ 28] have presented additional evidences that represent opposing views on the role of JA signaling in modulating the establishment of SAR.
The subfamily-1 receptors of Arabidopsis play the predominant role in ethylene signaling [18], [19], but the degree to which His kinase activity contributes to ethylene signal transduction is not resolved, although it has been implicated in modulating both the establishment of and the recovery from the ethylene response [18], [20], [21].
Other genes modulated earlier in the establishment of resistance include two adenosylhomocysteinases, an aspartokinase-homoserine dehydrogenase and a serine carboxypeptidase.
Soluble factors released by astrocytes such as cholesterol or thrombospondins have been shown to modulate spine formation and the establishment and maintenance of synaptic contacts [19], [20].
M2 is a MHV-68 encoded protein that modulates signalling pathways linked to the establishment of viral latency in B cells.
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