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Recent epidemiological and in vivo studies suggest that B vitamins might be particularly protective against air pollution-induced cardiovascular effects—as it was demonstrated to modulate the epigenetic and inflammatory signaling pathways linking air pollution, intermediate biomarkers, and cardiovascular outcomes6,17,27,28.
Polycomb Repressive Complexes (PRC) modulate the epigenetic status of key cell fate and developmental regulators in eukaryotes.
Cancer cells modulate the epigenetic machinery to silence tumor and metastatic suppressors to gain selective growth and invasive properties [4], [5], [6].
MiRNAs targeting methyltransferases or HATs could be used to modulate the epigenetic mechanisms involved in the maintenance of metabolic memory.
Based on our observations, we propose that these lncRNAs might modulate the epigenetic state of nearby coding genes.
Furthermore, prenatal sGC exposure alters the expression of several genes encoding proteins that modulate the epigenetic state.
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The emphasis is on the role of intention in modulating the epigenetic landscapes to the emerging forms of infant motor development and how the evolution of attractor landscape dynamics in infancy arises from the multiple time scales of constraints to action.
This suggests that the presence of S10ph modification has an important role in modulating the epigenetic marking of facultative heterochromatin by H3K9me3 during cell differentiation.
In mammalian dosage compensation, the large Xist transcript along with its antisense counterpart, Tsix, are crucial in modulating the epigenetic state of X-linked loci (reviewed in [ 4]).
High glucose levels induce earlier senescence, while glucose restriction inhibits cell senescence and significantly extends cellular lifespan, probably by modulating the epigenetic control of gene expression [ 29- 31].
Thus, FAS1 modulates the epigenetic states of genes involved in the G2 damage checkpoint, while MGO1 acts in DNA repair and maintains the expression of several epigenetically regulated genes [ 24, 25].
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