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By sharing the same transport systems with arginine, the availability of dietary or extracellular lysine can modulate the entry of arginine into leucocytes and NO synthesis by iNOS.
We hypothesize that manipulating the adenosine-ARs axis on CNS barrier cells may represent an efficient way to modulate the entry of immune cells into the CNS and to limit CNS inflammation and pathology.
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Stretch-activated channels that modulate the Ca2+ entry can regulate mechanical strength and the organization of focal adhesion sites between a fibroblast and a substratum [ 112].
TRP channels regulate [Ca2+]i by directly acting as Ca2+ entry channels in the plasma membrane or by changing membrane potentials to modulate the driving force for Ca2+ entry [ 54].
Taken together, these observations clearly demonstrate that airway protease activity can modulate the efficiency of SARS-CoV entry into human ACE2-expressing airway epithelial cells, in a manner that is step-dependent on virus-cell attachment.
Hence for sperm examined in the absence of rheotactic flow, entry of external Ca2+ does not modulate the linkage between rolling and the flagellar beat.
All three entry-defective mutants were unable to modulate the expression of IFN-λ above the arbitrary two-fold threshold.
We have previously shown that Trisk 95 can modulate the mechanism coupling the depletion of intracellular Ca2+ stores to extracellular Ca2+ entry.
The SOCE mechanism is well placed to modulate the dynamic range of cone signaling beyond limits imposed by the activation range of voltage-operated Ca2+ entry.
It helps modulate the speed of neurotransmission.
The above curves modulate the Filter 2 cutoff.
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