Sentence examples for modulate the efficacy from inspiring English sources

The spacer unit was found to have a significant effect on biological activity, reinforcing the importance of the design of conjugate compounds to create new biologically active molecules in which the spacer could be useful to improve the solubility and to modulate the efficacy of well known anticancer drugs.

These findings suggest that inhibitory receptors can modulate the efficacy of immune responses against gammaherpesvirus infections.

As we show here, they can support viral replication and modulate the efficacy of a CRAd through the production of soluble factors.

Ca2+ plays a role in remodeling the actin cytoskeleton through the actin-binding proteins whose activity is regulated by Ca2+, e.g. gelsolin, but conversely the actin cytoskeleton itself may modulate the efficacy of the intracellular Ca2+-releasing mechanisms [15] [17].

In the current scenario of TB disease, AA could (a) modulate the efficacy of antitubercular regimens (that target replicating organisms) and, (b) contribute to TB control among immunocompromised individuals such as HIV subjects.

Such steroids modulate the efficacy of a sigma-1 receptor agonist in stress and depression [ 12].

Recently, the identification of a number of synaptic proteins as substrates or interacting proteins with Cdk5 provides important clues on how this kinase modulates the efficacy of synaptic transmission.

It has been debated whether the presence of CA modulates the efficacy of triptans in acute migraine treatment [20], as medications such as dihydroergotamine may reverse central sensitization [21].

Furthermore, clathrin-mediated endocytosis is also a regulator of the internalization of a subtype of ionotropic glutamate receptor, the AMPA receptor (AMPAR), that critically modulates the efficacy of glutamatergic neurotransmission as well as LTP and Long-term Depression [33].

However, higher diversity in NS2 was also associated with null response compared to relapse in the genotype 1a NR sequences [11], and therefore NS2 appears to play a role in modulating the efficacy of antiviral therapy.

When more than one record (i.e., one row of the database) exists for a given hypothesis (e.g., BRAF mutation V600E modulates the efficacy of small molecule inhibitor sorafenib), we propose a score-based approach to make a summary of the available evidence.