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We had limited statistical power to evaluate the potential interactions with metabolic and repair genetic polymorphisms, which has been suggested to modulate the associations with air pollution (Topinka et al. 1997).
We discuss possible confound-ers in the subsequent sections, particularly from dermal exposure to formaldehyde and respiratory infections that can possibly modulate the associations in the studies we reviewed for human formaldehyde hematotoxicity.
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We and others have presented evidence that age can modulate the association of SLC6A3/DAT1 with ADHD, with different haplotypes of the gene being associated with ADHD in childhood and adulthood (Barkley et al. 2006; Elia and Devoto 2007; Franke et al. 2008).
It may thus be envisioned that activation of the glucocorticoid receptor stimulates signaling pathways that modulate the association of RNA-binding proteins to the utrophin 5'UTR, thereby enhancing IRES-mediated translation.
Prior reports have shown that gender may modulate the association between APOE gene and related neuropathology [9], [25], [26], and therefore may potentially affect the result of HRV analysis.
Genetic predisposition might greatly modulate the association of environmental factors with PD.
Genetic predisposition may also modulate the association between vascular risk factors, diabetes, and dementia [ 20].
Whether genetic variants in UGTs could modulate the association between fluid intake and bladder cancer has not been studied.
These results suggest that MAOA genotype may modulate the association of impulsiveness and ALFF in pons, and the association was only shown in MAOA-L group.
Chronic hyperglycemia also may modulate the association, as the impact of metformin was less evident in patients with high HbA1c levels.
To investigate the role of factors that modulate the association between alcohol and mortality, and to provide estimates of absolute risk of death.
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