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In support of this view, hCdc14B has been shown to modulate the assembly and disassembly of the mitotic spindle by bundling and stabilizing microtubules, yet apparently independent of its catalytic activity [28].
It should be further noted that DMEM is known to contain a wealth of ions, amino acids, and other compounds needed for the sustenance of cultured cells, exemplifying an environment that is most likely to be found in vivo; in turn, the charged and organic substrates contained in DMEM may very well modulate the assembly of nanoparticles!
And in fact bacteria use the cycle of nucleotide hydrolysis to modulate the assembly of their cytoskeletal filaments quite nicely.
With 'inside-out' signaling, integrin activation might modulate the assembly of ECM ligands on the cell surface.
Recent studies suggested that some multi-subunit tethering complexes could also directly modulate the assembly of functional SNARE complexes (reviewed in Hong and Lev, 2014).
In addition to these functions, Cbl proteins modulate the assembly of signaling proteins downstream of the M-CSF receptor (c-Fms) and RANK that are required for osteoclastogenesis.
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The CFP is capable of modulating the assembly of NiCo-LDH nanoplates, yielding the vertically oriented nanoarrays on CFP.
The nature of effects (from repression to activation with additive or multiplicative effects) may depend on how factors synergize or compete in recruiting co-activators such as CBP/p300, in modifying local chromatin complex and in modulating the assembly of transcription initiation complexes.
Current studies involve the use of imaging methods, including atomic force microscopy (AFM), electron microscopy (EM) and total internal reflection fluorescence microscopy (TIRFM) to understand the role(s) that GTP plays in transposition, the detailed reaction pathway and how this cofactor modulates the assembly and activity of transposase on DNA.
Ral GTPases are thought to participate to vesicle docking by modulating the assembly of the exocyst complex [12].
The results were consistent with previous reports in which full-length wt αB crystallin interacted with tubulin and modulated the assembly of tubulin into microtubules [17], [21].
More suggestions(15)
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modulate the cation
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modulate the effect
modulate the invasion-metastasis
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