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The first level, growth factor modulators (GM class), are secreted molecules that modulate the activities of receptor-binding secreted factors.
These differences in their substrate specificity may be due to differences in their CXXC active site pocket (27), known to modulate the activities of oxidoreductases (25).
Furthermore, gabapentin is able to modulate the activities of P/Q- and, to a lesser extent, N-type high voltage-activated channels located presynaptically at the cortical level and controls the neurotransmitter release, in particular that of glutamate.
Oligosaccharides transact information exchange at the cell surface and modulate the activities and distribution of proteins within cells.
The opposing activities of HATs and HDACs can modulate the activities of diverse transcription factors and regulatory proteins (Glozak et al., 2005; Wang, 2011).
Although many membrane additives are known to modulate the activities of membrane proteins via perturbing the properties of lipid membrane, the underlying mechanism is often not precisely understood.
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ROS are known to modulate the activity of the TNF receptor activated kinase JNK.
And at least two previous studies suggest that people can reduce the sensation of pain by learning to modulate the activity in an area of their brain.
Instead they seem to modulate the activity of other genes involved in listening.
Symington et al. (1999) assessed that pyrethroids can modulate the activity of voltage-gated calcium channels.
Vitamin D has been shown to modulate the activity of metalloproteinase enzymes.
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