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They seem to modulate the access of substrates to the prosthetic group at the distal side as well as the flexibility and character of the bond between the proximal histidine and the ferric iron.
Nucleosomes facilitate the packaging of the eukaryotic genome and modulate the access of regulators to DNA.
While little variation in metformin plasma pharmacokinetics was explained by polymorphisms in OCT1, polymorphisms in that gene appeared to modulate appeared to modulate the access of metformin to its target sites in the liver cell [ 63].
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This physical barrier modulates the access of insulin vesicles to the plasma membrane hence hampering exocytosis [25], [33].
Perilipins also regulate lipolysis by modulating the access of hormone sensitive lipases (HSL) to the surface of lipid droplet [ 47].
Thus, the circulating SHBG level is a major determinant of the metabolic clearance of sex hormones, modulating the access of such sex hormones to their target tissues.
We have shown that blockade or genetic lack of α4-integrins on T cells selectively modulated the access of T helper cell subsets to the CNS.
Firstly, Translation Factor eIF6, also demonstrated in the western blot, which can regulate translation by modulating the access of the large ribosomal subunits to the elongation cycle, binds to 60S subunits which are activated by release of eIF6 [ 48].
Together, these findings suggest that VEGF-mediated structural changes at the brain-hypothalamic barrier, by modulating the access of blood-borne metabolic substrates to the ARH, play an important role in the adaptive response to fasting.
Chromatin dynamics tightly controls activation and function of genes, by modulating the access of regulatory factors to DNA, and highly influences cellular behavior of normal and neoplastic cells [ 21].
Determining the factors that modulate the early access of abstract lexical representations is imperative for the formulation of a comprehensive neural account of visual-word identification.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com