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Moreover, attempts to modulate the abundance of selected proteasomal subunits failed, although transcript abundance was strongly increased in the generated overexpression strains.
Similarly, histamine did not modulate the abundance of late differentiation markers, when intact human skin biopsies were incubated with histamine ex vivo (Fig. 3D).
All this evidence only underscores the complex regulation of the Mb gene in breast carcinomas, in which hypoxia/HIF signalling is just one of several stimuli to modulate the abundance of this hemoprotein.
Experimental approaches to modulate the abundance of a given lipid unavoidably lead to changes in the abundance of other interconverted lipids such that manipulating the concentrations of one lipid in isolation seems impossible.
On the basis of our working hypothesis, we postulate that one of the AIF physiological functions is to modulate the abundance as well as the function of the MIA40 protein.
Chemical inhomogeneities in microenvironments such as salt or pH gradients, phospholipid background structure, etc. may further modulate the abundance of all or a selection of signals in MALDI spectra.
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These NOVA proteins can also shuttle from the nucleus to the cytoplasm, and it is thought that they can modulate the abundances of proteins in neuronal cells by helping to localize RNA to dendrites (Racca et al., 2010).
In soft-bottom tidal flats, sediment stability is one of the crucial parameters modulating the abundance and composition of benthic assemblages.
We have developed a strategy for dynamically modulating the abundance of native enzymes within the host cell and applied this to a model system for myo-inositol production from glucose.
Using a weight loss program, Ley and colleagues [7] demonstrated that a decrease in the F/B ratio in obese individuals correlated with weight loss over time and suggested that modulating the abundance of specific bacterial communities might be beneficial in the treatment of obesity.
In contrast, most macromolecular therapies focus on targeting a single receptor or modulating the abundance of a single gene product.
More suggestions(15)
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