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It can modulate synaptic plasticity, neurogenesis, neural growth and differentiation [3].
Together, these results suggest that GluR6 Q/R site RNA editing may modulate synaptic plasticity and seizure vulnerability.
If nonlinear processing occurred in the dendritic tree during the forward propagation, this means that somatic spiking can modulate synaptic plasticity even when one or more layers of nonlinearities lie between the synapse and the soma.
Brain-derived neurotrophic factor (BDNF), a neurotrophin, is known to promote neuronal differentiation stimulating neurite outgrowth in the developing CNS, and is also known to modulate synaptic plasticity, thereby contributing to learning and memory in the mature brain.
Morphine has also been shown to modulate synaptic plasticity at hippocampal glutamatergic synapses [58].
MMP9 binds also to synaptic integrins that anchor or position them to cleave other target substrates to modulate synaptic plasticity [35].
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Ubiquitin-proteasome system (UPS) has emerged as major molecular mechanism which modulates synaptic plasticity.
Furthermore, GLP-1 peptides are not only effective in modulating insulin-release and achieving glycaemic control in type 2 diabetes, but are also effective in modulating synaptic plasticity.
Yet there is also extensive evidence that dopamine acts as a learning signal, modulating synaptic plasticity within striatum to affect future behavior.
The concept of the meta-neuron is inspired by the role of astrocytes in modulating synaptic plasticity in biological neural networks.
At postnatal and adult stages, reelin modulates synaptic plasticity [15], [16] and dendritic growth [17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com