Sentence examples for modulate survival in from inspiring English sources

However, it is the mainstream supportive therapy that can modulate survival in this syndrome.

Some studies have even reported that genetic aberrations in serum DNA modulate survival in NSCLC patients treated with chemotherapy.

The effect of PTK6 downregulation on apoptosis is specific for matrix-deprived cells as downregulation of PTK6 had no effect on attached IGF-1R cells (Figure 2A), supporting the specificity of the screen in identifying genes that modulate survival only in matrix-detached conditions.

Thus, not only is the theoretical basis for the use of MEK inhibition to modulate survival signalling in place but effective drugs are available, and the target is overexpressed in breast cancer.

Hence, the present report shows that the proposed roles for PKDs as key sensors that modulate survival pathways in response to oxidative stress and regulate cell survival and proliferation are not ubiquitous and may be restricted to certain cell lineages.

It suggests that VEGF and VEGFR-1 may modulate survival of lung epithelial cells in an autocrine fashion.

These signaling pathways also modulate osteoclast survival in response to RANKL and M-CSF.

It is presently unknown whether oxidative stress induced by iron alters autophagy to modulate cell survival in normal and malignant ovarian cells.

As discussed below, this concept was developed in breast cancer by combining FTIs with tamoxifen, an endocrine agent that is well known to modulate cell survival in ER-positive breast cancer cells.

These results suggest that the MAPK signaling pathway is essential in modulating cell survival in response to FAC in a Ras-dependent manner.

Conversely, inhibition of PKCι and the closely related PKCζ by the prostate apoptosis-response 4 (PAR-4) protein has been recently shown to increase proteolytic processing of amyloid precursor protein [56], [57] and to exacerbate Aβ accumulation and toxicity in mouse models of Alzheimer's disease [58], [59] suggesting a role for PKCι in modulating survival.