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In other words, the positions of the cleavage sites are essential determinants for how calpains modulate substrate functions.
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It remains an open question what proportion of the tens of thousands of phosphates detectable in the cell serve to modulate substrate function: perhaps it is a minority.
Given the structural variability of clades I and II, and differences in measured catalytic functions, it is likely that these structural differences help to modulate substrate selectivity between chitin and cellulose in AA10, as now predicted for AA9.
Strategies that modulate substrate metabolism in astrocytes would be innovative approaches to address impaired neuronal function and neurodegeneration with age.
CK2 β mediates interactions between the catalytic subunits and many of its substrates, thereby modulating substrate selectivity and catalytic activity.
To address this issue, we modulated substrate compliance using fibronectin-coated acrylamide-based hydrogels.
The vasocrine action on nutritive tissue flow has been involved in modulating substrate fluxes to organs.
Kinases recognize and phosphorylate their specific substrates and modulate their functions.
Therefore, prediction of cleavage sites by calpains is crucial to gain insight into how calpain proteolysis modulates cellular functions through substrate proteolysis [8].
Kinases directly interact with and phosphorylate downstream substrates, thus modulating their functions.
WNK8 appears to modulate some functions of EDM2.
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