However, our understanding of the cellular and molecular mechanisms employed by DA neurons to modulate striatal function remains incomplete.
These results suggest that the anatomical localization of iron may underlie the effects of maternal TURP and/or iron supplementation to modulate striatal DA transmission, as opposed to cortical DA function, although it does not fully explain the differential effect between NAcc and dSTR.
Circulating insulin levels dynamically modulate striatal DAT activity, with decreased DA uptake and DAT surface expression seen in animal models of diabetes and after food restriction (FR 20,21.
Both regions show evidence of decline in human aging, but behavioral research suggests greater decline in HC versus striatal functions.
Together, the regions in this network, including the OFC, pallidum, amygdala, hippocampus, and temporal pole, integrate information related to reward processing, emotion, and memory to modulate striatal activity [15].
Variations of DA concentration can modulate striatal death in various models [5], [6], [7].
Cdk5 has been suggested to both increase [41], [42] and decrease [43] neurotransmitter release and modulate striatal neuron excitability [1].
We predicted that feedback would engage the striatum and that beliefs about task difficulty would modulate striatal feedback responses during learning.
We have shown that task difficulty expectations modulate striatal sensitivity to positive versus negative feedback for individuals with high normative goals.
These findings shed new light on dopaminergic modulation of hippocampal-striatal functions in PD.
