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There are evidences that tenascin and TSP-1 modulate sprouting of endothelial cells [ 50].
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VEGF modulates destabilization, proliferation, invasion, and sprouting of vessels, thereby orchestrating the formation of neovasculature via signaling through its receptors VEGFR1 and VEGFR2.
Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.
It is possible that hypoxia (and also dense intercellular contacts) upregulate expression of endosialin to relieve pericyte endothelial interactions and/or to modulate local tumour stroma, and thereby facilitate migration of dividing endothelial cells and sprouting of new blood vessels.
The meeting mainly consisted of a sprouting of ideas.
A sprouting of unheard music arriving after months of cultivation.
In a second strategy, we explored GOF approaches to modulate fin sprouting.
Likewise, engineered anti-sense suppression of AChE modulates neuronal sprouting in the mouse hippocampus (Sklan et al. 2006).
In addition, DLL4 has been described to modulate endothelial sprout and angiogenesis in CRC (Noguera-Troise et al, 2006).
Also, miR-21 is crucial in regulation of heart valve formation by modulating the expression of sprout homolog (sprout), programmed cell death 4 (pdcd4K), and phosphatase and tensin homolog B (ptenb) (Banjo et al. 2013).
MiR-100 has an antiangiogenic function by modulating proliferation, tube formation, and sprouting activity of endothelial cells and migration of vascular smooth muscle cells and functions as an endogenous repressor of the serine/threonine protein kinase mammalian target of rapamycin (mTOR) [ 35].
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