Our data suggest that Math6 contributes to endocrine differentiation by modulating specific aspects of Neurog3 function.
Furthermore, even in response to the same stressor, TG2 differentially modulates specific aspects of the cell death pathway, even in opposing directions.
In mouse, ATOH8 has been found to contribute to endocrine differentiation by modulating specific aspects of Neurog3 function (Lynn et al. 2008).
Thus, TIA proteins modulate specific and overlapping negative aspects of cell proliferation, apoptosis, the cell cycle and cancer-related pathways, which may contribute to the cellular phenotypes associated with sustained expression of TIA proteins.
Taken together, these data indicate that OvCar-3 and PC-3 OPNc-overexpressing cells modulate specific transcriptional patterns related to key aspects of cancer progression, although part of these signaling pathways is commonly regulated in both cell-line tumor models.
The identification of MYB genes in grapevine opens the possibility of modulating MYB gene expression in order to control specific aspects of grape physiology and development.
Thus, this new knowledge of the PLD gene family in these species may lead to the possibility of modulating PLD gene expression and function in order to control specific aspects of the physiology and development of woody plants.
In this study, we use three types of such information: that base changes within two bases of a splice site abolish splicing at that position [ 19], that some base changes close to a splice site may modulate splicing at that position [ 20], and that missense base substitutions affect specific aspects of protein function.
However, it could be the case that OCP3 is regulating specific aspects of the oxidative plant cell status that in turn modulates the cytosolic function of NPR1 required for the activation of JA-dependent induced defenses.
