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Other components that potentially modulate signal transduction of TGF-β members derive from the large group of modulator proteins, e.g., noggin, follistatin, and members of the chordin and DAN family.
Phosphoinositides and ubiquitination are major systems that modulate signal transduction in space and time.
In the cytoplasm, FKBPs and these drugs modulate signal transduction pathways.
Coupled to hundreds of receptors, G-proteins modulate signal transduction pathways and are important hormonal targets.
Members of the SH2 domain family modulate signal transduction by binding to short peptides containing phosphorylated tyrosines.
These findings indicate that green tea and theophylline as well as other chemopreventive agents that modulate signal transduction may have opposite effects on cancers of different histolopathology and cell lineage.
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Sulfated glycosaminoglycans (GAGs) are known to interact electrostatically with positively charged growth factors to modulate signaling.
It has a lot to do with neurotransmitters (endogenous chemicals that relay, amplify, and modulate signals between a neuron and another cell) and how food affects them.
More recent data also suggest salicylic acid and its derivatives modulate signaling through NF-κB.
To fully appreciate how PTMs modulate signaling networks, proteome-wide studies are necessary.
Proteins containing BCH domain are thought to modulate signaling networks.
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