L-Cysteine limitation also modulates several proteins associated with these processes in E. histolytica.
Wnt proteins modulate several major signaling cascades including canonical (β-catenin-dependent) and noncanonical (β-catenin-independent) Wnt signaling pathways.
FOXO transcription proteins modulate several cellular functions including proliferation, apoptosis, stress resistance, inflammation migration, and metabolism through regulation of multiple transcriptional targets.
This direct action has been found to modulate the function of several proteins important in myocardial function such as G-protein coupled receptor kinase2 [ 63], HIF-1α [ 34], and the ryanodine receptor [ 64].
Although protein kinase C has been shown to phosphorylate and modulate the activity of several proteins involved in the Ca2+ signaling pathway and Ca2+ transport, the physiological significance of the protein kinase C in agonist-stimulated cell function requires further elucidation.
PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking.
YAP1 has been reported to bind and modulate the transcriptional activities of several proteins such as Runx2, TEAD, p73, ErbB4, Smad7 and Smad1 [ 7, 10- 15].
FKBPs are multifunctional proteins that modulate several signal transduction pathways.
CaMKII is a serine/threonine protein kinase that modulates several Ca2+-dependent proteins, such as SR Ca2+-release channels (ryanodine receptors, RyR2), phospholamban (PLB) which regulates SERCA and L-type Ca2+-channels.
The expression of several proteins which mediate contact inhibition are modulated by MIF.
