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Tan, E. K. et al. Multiple LRRK2 Variants Modulate Risk of Parkinson Disease: A Chinese Multicenter Study.
These findings suggest that genetic variants of MBD4 rs140693 may modulate risk of lung cancer.
It is hypothesized that the interaction of genes encoding for type V and XI collagens could modulate risk of Achilles tendinopathy, allowing for the possibility that the effects of type XI collagen variants in the developing tendon might affect the structural or functional properties of the mature tendon [25].
The association between FTO and obesity has been shown to indirectly modulate risk of type 2 diabetes in Europeans [6], [10], [34], but it has been difficult to demonstrate an association between FTO (rs8050136) and obesity or BMI in Asians [35] [37].
Polymorphic LRRK2 variants have also been shown to modulate risk of PD [ 4– 7].
NIAAA contributes to this effort, with a special focus on those genes known to be involved in brain function and suspected to modulate risk of alcoholism.
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We hypothesized that p73 G4C14-to-A4T14 polymorphism modulates risk of second primary malignancies (SPM) in patients after index SCCHN.
Our study adds to mounting evidence supporting a role for genetic variation in modulating risk of AKI.
Several recent studies have investigating how genetic susceptibility modulates risk of adverse pregnancy outcomes from environmental exposures such as cigarette smoke.
As well as increasing with age, this disease is more common in the male versus female population internationally, which has led to interest in the potential role of sex hormones in modulating risk of development of atherosclerosis.
None of the women in our study reported a diagnosis of gestational diabetes, but subclinical alterations in glucose regulation due to arsenic toxicity are likely to be present, and may play a role in modulating risk of neural tube defects.
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