Sentence examples for modulate receptor internalization from inspiring English sources
The binding of some allosteric ligands may modulate receptor internalization and thus also fail to be detected by many functional assays and indirect signaling screens.
Upon ligand binding to the active domain of HER1, HER3 or HER4, these receptors can activate homodimeric or heterodimeric receptor complexes – but they preferentially recruit HER2 into a heterodimeric complex in which the HER2 kinase can modulate receptor internalization and prolong signal transduction.
Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization.
Therefore, cadherins can modulate the response to growth factors by inhibiting receptor internalization in addition to sequestering the cytoplasmic factors, such as β-catenin, needed for transcriptional regulation of the genes downstream of the growth factors.
It is becoming clear that the regulation of the GPCR itself – its location, stability, and signal duration – is a key component of the signaling process [ 1, 2] The length of a GPCR signal can be modulated by receptor desensitization (decrease in receptor responsiveness) and receptor internalization (trafficking of receptors to endocytotic vesicles).
Modulation of A(2)a receptor antagonist on D(2) receptor internalization and ERK phosphorylation.
Indeed, 5-HT3 receptor agonists and antagonists have been suggested to modulate cell surface receptor levels (Ilegems et al., 2004; Freeman et al., 2006; Rojas et al., 2010b), with receptor internalization being reported in the enteric nervous system following excess 5-HT (Freeman et al., 2006) and in recombinant systems, following exposure to palonosetron (Rojas et al., 2010b).
FLAG-tagged receptors reveal specificity of limited D2 receptor internalization.
TNF receptor internalization also leads to acid (a SMase activation.
Nong, Y. et al. Glycine binding primes NMDA receptor internalization.
This would account for the lack of D2 receptor internalization in dopamine neurons versus the internalization observed in LC neurons.
