Sentence examples for modulate receptor function from inspiring English sources
Ligand association at these interface sites may modulate receptor function.
Determining the critical structural features a ligand must possess in order to bind to its receptor is of key importance to the understanding of vital biological processes and to the rational design of small molecule therapeutics to modulate receptor function.
Mechanisms, however, by which the antibodies modulate receptor function are poorly understood.
Because of the highly conserved nature of the orthosteric binding site, ligands that modulate receptor function at this site have poor subtype selectivity among the mGlu receptors.
It is unclear whether these varying binding properties have implications for the ability of a specific antibody to modulate receptor function.
Patient antibodies could potentially modulate receptor function independently of their ability to internalize NMDARs because the epitope is within the N-terminus of GluN1, 24 a region that also contains the ligand-binding domain.
We determined that the neuroprotective effects of IL-21R arose from signaling through JAK/STAT pathways and upregulation of caspase 3. Thus, natural genetic variation in murine Il21r influences neuronal cell viability after ischemia by modulating receptor function and downstream signal transduction.
Neurosteroids are synthesized in central nervous system, able to modulate GABAA receptor function and has been reported to have neuroprotective action.
The organic acids increased total lateral pressure (surface pressure) of DPPC monolayers, including at mean molecular areas typical of bilayers.IVA, MMA, and propionic acid have anesthetic effects in tadpoles, positively modulate glycine receptor function and affect physical properties of DPPC monolayers.
In addition, IL-1beta could positively modulate NMDA receptor function [ 24].
The slow glutamate responses are mediated by metabotropic glutamate receptors (mGluRs) through G-protein coupling with numerous intracellular signalling cascades that can modulate ionotropic receptor function [ 1].
