Sentence examples for modulate receptor conformation from inspiring English sources
Since β1AR autoantibodies recognize conformational epitopes, they are thought to modulate receptor conformation or influence the stability of transient conformational states induced by true ligands.
Consistent within these approaches is the observation that receptor-ligand molecular interactions are mediated through specific structural determinants that modulate receptor conformation and thus transactivational capacity.
The role of cholesterol in the interactions of AHLs with membranes, the significance of modulating cellular dipole potential for receptor conformation and the implications for immune modulation are discussed.
One possible mechanism to explain these pleiotropic effects is that the antibodies induce or stabilize changes in receptor conformation that mimic or modulate the ones induced or stabilized by true agonistic ligands (see Figure 1B).
For example, cholesterol can modulate the activity of some GPCRs [ 39, 40], can affect receptor conformation [ 41] and has been co-crystallized with GPCRs, which led to a 'cholesterol consensus motif' being proposed as part of a specific cholesterol-binding site within the architecture of some GPCRs [ 42].
Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function.
Ligand association at these interface sites may modulate receptor function.
The results suggest that the receptor conformation and sensitivity to glycine and ethanol are different in distinct brain areas.
We present evidence that, like receptor phosphorylation, receptor dephosphorylation is tightly regulated, requiring a specific receptor conformation induced by vesicular acidification.
Some methods consider only one receptor conformation.
15 Specifically, these approaches have been based on inhibiting the kinase activity of mutant EGFR or Met by selective inhibitors that target mutant receptor conformations, thereby modulating the EGFR or c-Met downstream signaling pathways.
