Sentence examples for modulate protein turnover from inspiring English sources

Phosphorylation has been shown to modulate protein turnover, localization, interaction and activity for various molecules in eukaryotes.

In our recent efforts in search of novel cellular factors that modulate protein turnover, HSP70 was found to interact with OLA1 (Obg-like ATPase 1), a newly identified ATPase member of the YchF subfamily GTPases.

Glutamine is important for tissue repair, is used for cell proliferation and can stimulate collagen synthesis 11. β-Hydroxy-β-methylbutyrate is a naturally occurring metabolite of the amino acid leucine, inhibits proteolysis and modulates protein turnover 12.

A second mechanism through which SIRT1 has been shown to influence neurodegenerative disease is by modulating the protein turnover of proteotoxic species by direct deacetylation.

It was proposed that µ-calpain cleaves CDKN2D after the R25, H29, Q47, G64, L113 and A127 residues, and plays an important role in modulating cell cycle regulatory protein turnover [27].

Activity of these proteins is post-translationally modulated by either phosphorylation or protein turnover, by the ubiquitin-mediated proteolysis complexes, SCF and APC.

Nevertheless, our current understanding of the molecular mechanisms by which human muscle protein turnover is modulated by amino acids and insulin is poor.

AAA+ proteases are frequently regulated by adaptors that modulate spatial and temporal control of protein turnover.

Accordingly, the signalling pathways that regulate protein turnover are strongly modulated over the course of this process (Drummond et al. 2009, Miyabara et al. 2010).

Moreover, our data suggest that GSK-3α might control AKT protein turnover, while GSK-3β could modulate MCL-1 protein stability.

The regulation of AP-1 activity is complex, which can be achieved by modulating jun and fos gene transcription and mRNA turnover; Jun and Fos protein turnover; post-translational modifications of Jun and Fos proteins that modulate their transactivation potential; or interactions of AP-1 with other transcription factors that can either synergize or interfere with its activity.