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These pathways modulate protein translation via the eIF4 family proteins.
As miRNAs have the potential to modulate protein translation independent of degrading the mRNA for a specific target, we analyzed our data in the context of a previously published protein database for lung development [26].
These short, non-protein-coding RNAs modulate protein translation from specific mRNAs [ 10].
Sch9/S6K1 then targets ribosomal protein S6 and other regulators to modulate protein translation initiation and ribosome biogenesis.
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In agreement with our previous observation that Nck1 modulates protein translation [ 20], we observed a decrease in general protein synthesis in HepG2 cells depleted of Nck1 as measured by S-Met/Cyst incorporation (unpublished data).
It can bind DNA, RNA and proteins, and can modulate transcription, protein translation and protein stability [13].
Thus, the overall results supported that exons 1A and 1B were acting as 5'UTRs that modulate SHBG protein translation.
Therefore, we speculate that following initiation of MMR processing of chemotherapy drugs such 6-TG and 5-FU, p53 is activated and functions as a transcription factor to upregulate BNIP3 transcription, while mTOR-S6K1 modulates BNIP3 protein translation.
microRNAs (miRNAs) constitute a new class of small noncoding RNAs that control post-transcriptionally the expression of gene products, either modulating directly protein translation or regulating the stability of messenger RNA.
Further studies are required to elucidate the mechanisms by which Myc activation modulates transcript-specific protein translation, and whether these effects are directly regulated by Myc (in a transcription-independent mode) or are secondary to its activation and mediated by Myc-responsive regulators (e.g., RBPs, miRs).
Lack of FcεRI-γ protein upregulation by TNF, IL-1β or IL-4 may suggest some post-transcriptional regulatory mechanisms modulating the FcεRI-γ protein translation.
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