Sentence examples for modulate protein stability from inspiring English sources
Charge charge interactions on the surface of native proteins are important for protein stability and can be computationally redesigned in a rational way to modulate protein stability.
In addition, Sox17 and Sox4 respectively inhibit and enhance proliferation of colon carcinoma cells through physical interactions with β-catenin and TCF/LEF to modulate protein stability and transcriptional activity, and Sox6 interacts with β-catenin and HDAC1 to repress cyclin D1 promoter activity and proliferation in insulinoma cells [52], [53].
Recent reports have proposed that S-nitrosylation can modulate protein stability [7], activities [8] and trafficking [9], [10], and play an important role in a variety of biological processes, including transcriptional regulation [7], cell signaling [11], apoptosis [8], and chromatin remodeling [12].
In p53, modifications modulate protein stability, DNA binding and transcription.
Multiple extracellular signalings, such as growth factor signaling and genotoxic stress, impact these regulators, which in turn modulate protein stability of p63 [ 9, 10].
CSN associated kinases phosphorylate substrates of the UPS which modulates protein stability (Hannß and Dubiel, 2011).
Moreover, we modulated protein stability throughout the entire trajectory using overexpression of GroEL/ES to avoid evolutionary dead ends caused by stability bottlenecks (Socha and Tokuriki, 2013; Wyganowski et al., 2013).
Many examples of how intrinsic disorder modulates protein stability have been noted in other systems, including the immediate post-translational degradation of the Neurospora crassa clock protein FRQ when not in complex with its partner, FRH.
Importantly, this diagram helps predict differential expression of the genes that may have profound biologic consequences (i.e., by modulating protein stability or activation level) that are not observable in a gene expression microarray.
Since the association between Aurora-A and PUM2 is necessary for enhancing the stability of Aurora-A, PUM2 should first physically interact with Aurora-A and then modulate its protein stability.
Phosphorylation of PML can also modulate PML protein stability.
