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Rational modification of epitope GlcNAc puckering kinetics can be expected to modulate protein recognition and thereby facilitate development of therapeutics (Jefferis 2009).
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Upon molecular recognition a ligand can modulate protein function, thereby enhancing, inhibiting or modulating its activity.
In the past decade, our understanding of protein recognition has served as solid basis for the design of synthetic mimetics to modulate these protein protein interactions.
Recognition of gene phenotypes of proteins is a central challenge of the modern genetics to modulate protein functions and biological processes, and many well-known diseases, such as HIV [ 1– 4], cancers [ 5– 8], chronic liver diseases [ 9], and Gaucher disease [ 10], are all closed to protein phenotypes.
My laboratory studies how kinase inhibitors modulate protein signaling in patients with cancer.
How does translation elongation kinetics modulate protein folding?
Tuning protein recognition at the molecular level.
This modification can modulate protein function [24].
These pathways modulate protein translation via the eIF4 family proteins.
Allosteric effectors have the ability to modulate protein-ligand interactions in a controlled fashion.
Since β-turns usually occur on the exposed surface of a protein, they are well suited to participate in ligand binding, molecular recognition, protein-protein, or protein-nucleic acid interactions, thus modulating protein functions and intermolecular interactions.
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