However, there are multiple ways salt ions can modulate protein interactions.
The study of protein interaction networks is important not only from a theoretical point of view, but also has strong practical applications towards the development of new drugs, which could specifically interrupt or modulate protein interactions [51], [52].
These findings raise the interesting possibility that cell cycle mediated phosphorylation of Rbf1 can modulate protein interactions while Rbf1 remains tethered to specific chromosomal sites, such as origins of replication through its association with ORC and/or Myb-MuvB.
We conclude that the function of polyQ tracts is to modulate protein interactions in the context of specific surrounding sequences.
Interestingly, this region may also play a role in mRNA-specific regulation by individual PABP proteins [ 5], consistent with the idea that these modifications could modulate protein interactions important for mRNA-specific, rather than global, control.
Since the ECM forms a dynamic component towards mediating tumorigenesis, the abilities of matricellular proteins to modulate protein interactions for various essential receptor-mediated signalling pathways prove critical for facilitating cell survival, proliferation, EMT, invasion and metastasis.
It is also possible that some B″ regulatory subunits utilize Ca2+ to regulate the activity of the holoenzyme (Janssens et al., 2009) rather than to modulate protein interactions within the complex.
Desulfation significantly increased the release of histone from chondroitin hydrogels (30.6 ± 2.3 μg released over 8 days, compared to natively sulfated CS with 20.2 ± 0.8 μg), suggesting that sulfation alone plays a significant role in modulating protein interactions with GAG hydrogels.
There is strong interest in developing small molecules that modulate protein-protein interactions (PPI), since such compounds could serve as drug leads or as probes of protein function.
Deconjugation of ubiquitin and/or ubiquitin-like modified protein substrates is essential to modulate protein-protein interactions and, thus, signaling processes in cells.
