Sentence examples for modulate protein function from inspiring English sources

Splicing can modulate protein function by changing functional domains, affinities for assembly of heteromeric complexes, or altering mRNA stability.

Posttranslational modifications modulate protein function, and HTT is subject to multiple functionally relevant modifications including SUMOylation, ubiquitination, acetylation, palmitoylation, and phosphorylation (for review, see Ehrnhoefer et al., 2011; Pennuto et al., 2009).

Alternative splicing has been shown to modulate protein function in plants.

Upon molecular recognition a ligand can modulate protein function, thereby enhancing, inhibiting or modulating its activity.

Finding small molecules that modulate protein function is of primary importance in drug development and in the emerging field of chemical genomics.

Thus, there is an urgent need for efficient platforms to develop probes that can modulate protein function in cells to validate drug targets and to develop therapeutic leads.

This indicates AS can modulate protein functions of Aux/IAAs through regulating their intercellular location.

In addition to modulate protein functions, AS can influence transcript stability through nonsense-mediated decay (NMD) or miRNA linked regulation [ 12, 13].

p300/CBP is a key enzyme in higher eukaryotes, where it acts as an effector in myriad major cellular signaling pathways, which modulate protein functions and gene expression in response to a variety of signals.

Recognition of gene phenotypes of proteins is a central challenge of the modern genetics to modulate protein functions and biological processes, and many well-known diseases, such as HIV [ 1– 4], cancers [ 5– 8], chronic liver diseases [ 9], and Gaucher disease [ 10], are all closed to protein phenotypes.

The traditional concept of a functional active site is based on the assumption that protein phosphorylation modulates protein function through the specific position of the phosphorylation in the protein sequence.