However, most studies investigating the site of progesterone action in modulating prolactin secretion have focused on the hypothalamus.
Ambient temperature modulates prolactin (PRL) secretion in birds.
As proposed by Alessio and Lucchini in their letter, these data reflect the complexity of the control of prolactin secretion, which is modulated not only by dopamine but also by several other neurotransmitters.
6 The endocannabinoids mimic the actions of Δ 9-THC in mouse behavioral tests, interfere with learning and memory, activate the hypothalamic pituitary adrenal axis, decrease hypothalamus prolactin secretion, decrease intraocular pressure, cause hypotension and bradycardia, and modulate the immune system.
The cell bodies of the dopamine system are located in the substabtia nigra of midbrain and project to the striatum of the basal ganglia to coordinate skeletal muscle contraction, moreover, DA innervations reaches out to the hypothalamus to regulate secretion of TRH and prolactin secretion, and then projects to the brain limbic system to modulate motivations and emotions [ 47].
These drugs effectively decrease prolactin secretion and tumour size.
In addition, prolactin secretion increases progressively during pregnancy.
The consequent drop in progesterone levels causes high levels of prolactin secretion, giving rise to milk production, an enlarged abdomen and a host of misdirected mothering behaviors.
These drugs result in a prompt decrease in prolactin secretion and a decrease in tumour size.
In addition, increased prolactin secretion may be caused by prolactin-producing pituitary tumours, such as lactotroph adenomas or prolactinomas, and by several systemic diseases, notably thyroid deficiency.
