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Variation in the neck-linker length has been shown to directly modulate processivity in different kinesin families; for example, kinesin-1, with a shorter neck-linker, is more processive than kinesin-2.
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In any of these scenarios, single-point mutations can completely block the ability of a GSM to modulate processivity or as reported by others actually switch the activity of a GSM to that of an iGSM.
Jinek, M., Coyle, S. M. & Doudna, J. A. Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.
Considering that TrCel7B has similar asymmetric subsite architecture to that of TrCel7A, asymmetricity alone does not seem to be sufficient for processivity in the degradation of crystalline polysaccharides.
They found that the loss of processivity in the W97A mutant was accompanied by a 29-fold increase in the degradation rate for single-polymer chains.
Alanine substitution of the corresponding residue in Est2p significantly impaired repeat addition processivity in vitro [31].
An essential cellular replication protein, proliferating cell nuclear antigen (PCNA) encircles the dsDNA and enhances the DNA polymerase delta processivity in eukaryotic replication.
One consequence of increased processivity in DNA replication would be the ability to retain additional copies of genes that could then potentially specialize and form more refined complexes.
Kinesin and myosin-V were shown to enhance each other's processivity in vitro.
As a result of this release, Pif1p reduces telomerase processivity in vitro.
Subsequently, the liberated P-TEFb is recruited by Brd4 onto promoter-proximal region to modulate the processivity of RNAPII [ 29, 35, 36, 61, 64].
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