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This resting-state network can modulate pain perception through autonomic and antinociceptive descending modulation networks [11].
Interestingly, it has recently been shown by means of fMRI that migraine patients present an increased antinociceptive activity, which the authors explained as a compensatory reorganization to modulate pain perception [31].
These receptors modulate pain perception and orthostatic balance [ 11].
There are currently various medicines available to treat IBS, including fiber, antispasmodic agents, and antidepressants to modulate pain perception [ 30].
Early neuroimaging studies found the COMT 158Val allele to be associated with impaired prefrontal cognition and physiology, which could contribute to schizophrenia risk [ 5], and to modulate pain perception and brain responses to pain [ 4].
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It was suggested, that anodal tDCS modulates pain perception by shifts of the resting membrane potential and consequent alteration of the corticospinal excitability at the stimulation site.
It has been observed that mindfulness meditation modulates pain perception as well, e.g. [ 320].
59 Lactobacillus acidophilus NCFM and Lactobacillus paracasei NCC2461 also modulate visceral pain perception in rodents.
More importantly, expectation of pain established and consolidated through associative learning can lead to affective responses similar to those evoked by acute pain, as well as coping responses that modulate subsequent pain perception [ 34].
The location of neuronal central and peripheral CB receptors indicates that activation of these receptors could modulate pain generation and perception [ 78, 82- 85].
ERs and aromatase are expressed in the central nervous system and local estrogen production may modulate pain and sensory perception [ 87].
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