Sentence examples for modulate p53 function from inspiring English sources

As a model to screen for genes that modulate p53 function, we previously developed a human fibroblast cell line named BJtsLT [11].

Both the genetic and environmental factors modulate p53 function.

The mechanisms through which hormones modulate p53 function are yet to be determined.

Whereas the ability of BAG-1S to modulate p53 function was modest and variable between experiments (mean inhibition from two separate experiments each carried out in duplicate (±s.d).d

It is equally possible that hormonal stimulation imparts a stable change in the stromal cells and extracellular matrix which modulate p53 function.

We sought to identify small molecules that could enhance the activity of p53 by combining the mdm2/p53-binding antagonist Nutlin-3 with small molecules known to modulate p53 function.

Current preclinical and phase I-III studies testing strategies to activate or modulate p53 functions should consider p53 functions independent from the classical view of protein or cell cycle regulations [ 8, 9, 30].

Moreover, KCNE peptides are known to affect the sensitivity of pharmacological agents that modulate Q1 function [22].

We next determined whether addition of MMP inhibitor could modulate CD46 function and notably IL-10 production.

The HSP90 inhibitor geldanamycin and its derivative 17-AAG modulate HSP90 function and facilitate the degradation of HSP90 client proteins [49], [50].

Since Math6 expression appears after Neurog3 in vivo and it is an early target of Neurog3 in vitro, we proposed that it might modulate Neurog3 function.