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In fact, particular dense packing of the DNA tertiary structure could account for deceleration of the replication rate and, therefore, modulate origin activity as well [27].
It has been suggested that epigenetic alterations influence fork rates both in yeast [19] [24] and in higher eukaryotes [25], [26], and that chromatin structure could modulate origin activity [27].
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Over-expression of Myc also affects DNA replication, modulating origin of replication activity and leading to replication stress and DNA damage [7].
Increases in the nucleotide pool can modulate origin choice and interorigin spacing 35, 36.
Future studies should focus on the interplay between GCN5 and other HATs in modulating the activity of origins and the subsequent steps in DNA replication.
This hints at another way in which changes in myelin distribution could modulate brain activity.
Gene therapy is an extension of drug and surgical treatments, and part of a continuum of medical interventions that introduce or modify DNA or modulate genes' activity.
By 2000, Allis and his colleagues around the world had identified a gamut of proteins that could modify histones, and so modulate the activity of genes.
And at least two previous studies suggest that people can reduce the sensation of pain by learning to modulate the activity in an area of their brain.
Furthermore, ionic compounds can modulate enzyme activity.
Symington et al. (1999) assessed that pyrethroids can modulate the activity of voltage-gated calcium channels.
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