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This occurs, in measure, by the ability of astrocytes to modulate networks of MP death and cell migration.
Immature dendritic cells also modulate networks of suppressive immune cells, such as T cells expressing the Foxp3 transcription factor.
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The most recent data highlight the role of decreased activity of the descending pain-modulating network, and of sensitization of central structures including the thalamus, periaqueductal grey matter, and spinal trigeminal ganglion [4].
Granulocytic differentiation of 32Dcl3 is induced by G-CSF and is suppressed by IL-3, suggesting that Xbp1S may modulate the network of cytokine signaling by switching downstream transcriptional regulation in differentiation processes.
The expression of numerous bacterial virulence factors is modulated through complex networks of regulatory molecules including two-component systems and global regulators such as agr or sar.
Our recent findings suggest that transcranial bright light (TBL) treatment via the ear canals modulates the neural networks of the human brain [ 39], improves cognitive performance in healthy participants [ 40, 41], alleviates symptoms of SAD [ 42], and acutely affects cardiovascular autonomic regulation [ 43].
It selectively suppresses helper T-cell function and modulates the network of inflammatory cytokines.
Cyclic adenosine monophosphate (cAMP), a naturally occurring secondary messenger, helps maintain homeostasis by modulating the network of pro-inflammatory and anti-inflammatory mediators [ 53]. cAMP levels are regulated by phosphodiesterases (PDEs), intracellular enzymes that convert cAMP to AMP [ 53].
The observed pleiotropic effect of LCA on a compendium of housekeeping longevity assurance processes implies that this bile acid is a multi-target life-extending compound that increases CLS in yeast by modulating a network of the highly integrated processes that are not controlled by the adaptable TOR and cAMP/PKA pathways.
Although this review focusses predominantly on changes to the efferent motor networks of neurons modulating bladder and bowel function, it should be noted that there is some data to suggest that sensory afferent pathways may also be affected by ageing in aged rodents.
Novel treatment paradigms based on drugs or interconnected networks of devices that modulate sensors are envisioned.
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