Sentence examples for modulate multiple targets from inspiring English sources

A pharmacological strategy for circumventing these drawbacks could involve designing multivalent ligands that can modulate multiple targets while avoiding the toxicity of a single-targeted agent.

In parallel, a new strategy is emerging that of developing a single chemical entity able to modulate multiple targets simultaneously.

Agents that modulate multiple targets simultaneously (polypharmacology) have the potential to enhance efficacy or improve safety relative to drugs that address only a single target.

Combination therapies, which modulate multiple targets simultaneously, are essential to achieve greater therapeutic benefit than using a single drug [ 65].

By activating CaSR without necessarily entering the cells, external calcium indirectly mobilizes intracellular secondary signaling molecules to modulate multiple targets including ion channels (Bouschet and Henley, 2005).

Hence "polypharmacology", the term used for drugs that bind to and modulate multiple targets, thereby eliciting several clinical effects, is an exciting and developing area of cancer research [ 91].

A single microRNA molecule is able to modulate multiple target genes; thus it is involved in multiple cell functions including proliferation, invasiveness, and differentiation [ 4].

The paradigm is shifting since many drugs elicit their therapeutic activities by modulating multiple targets, as indicated by the polypharmacology [1 3].

It should be noted that, without inspection of the individual documents or "prior knowledge", it is difficult to discriminate within database records per se between a bona fide drug target, a protein assay included for the purpose of discerning compound selectivity, off-target effects or modulating multiple targets with the same compound (i.e. polypharmacology) [21].

These in vitro and in vivo studies suggest that EGCG could reduce synovial hyperplasia, cartilage degradation and bone resorption by modulating multiple targets in joints [ 9].

Recently, with the growing understanding of complex diseases, the focus of drug discovery has shifted from the well-accepted "one target, one drug" model designed toward a single target to a new "multi-target, multi-drug" model aimed at systemically modulating multiple targets [ 19, 53].