Modulating innate mucosal immunity is promising as a rapid-acting, broad-spectrum approach to combat bioterrorism (1 ).
Lee, K.A. et al. Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila.
Fan, Y., Tang, Y. Y., Ma, Y. & Posner, M. I. Mucosal immunity modulated by integrative meditation in a dose-dependent fashion.
In addition to the antimicrobial spectrum exerted by the trio, IL-17A and –F may enhance mucosal immunity by modulating C. jejuni invasion and survival within IEC.
First, viral infection modifies the systemic effects of the host by modulating the host's immune response, which impairs mucosal immunity.
Probiotic diets are designed to modulate the intestinal flora to enhance mucosal immunity.
Enteral nutrition has proved to protect against postoperative sepsis by supporting mucosal immunity and to modulate the progression from gut ischaemia to systemic inflammatory response syndrome.
Yet, most commercial vaccines are delivered systemically, which only induces humoral immune protection without pathogen-specific mucosal immunity.
Mucosal immunity consists of innate and adaptive immune responses which can be influenced by systemic immunity.
Laboratory for Mucosal Immunity, RIKEN Research Center for Integrative Medical Sciences, Yokohama, Japan.
