Moreover, these lincRNAs might modulate the effects of multiple molecular functions, including binding, structural molecular activity, transporter activity, catalytic activity, and electron carrier activity, and they may exhibit translation elongation factor activity, unfolded protein binding activity, monooxygenase activity, ammonia-lyase activity and GTPase activity (Additional file 18).
Several of these genes have been shown individually to have roles in brain development and function, to modulate molecular processes involved in AD, and/or to display sex differences in their functional properties and consequences.
This is because advances in cellular biology and biochemistry allow medicinal chemists to design compounds capable of modulating receptor, enzyme, and other molecular functions that block or attenuate the symptoms of underlying disease.
Modulated genes were gathered together into 15 functional families [ 23], and classified as a function of the time when they were modulated (Table 2).-wrap-foot> The shading darkens as the number of modulated genes increases The functional analysis showed no obvious differences in the molecular functions of the modulated genes between aged or young groups.
In addition, the statistical analysis of molecular functions shows that bivalent genes modulate enzyme activity and protein interaction ability (Table 4).
Accumulating evidence suggests that RSV is a highly pleiotropic molecule that modulates abundant targets and thus influences numerous biochemical and molecular functions.
In order to assess the molecular functions and canonical pathways [ 12] modulated by L-OHP in the tested cell lines we performed the IPA Core Analysis.
The importance of CCN1 in tumorigenesis originates from its diverse molecular functions which influence tumor development and metastasis by modulating angiogenesis, epithelial mesenchymal transition (EMT), and anoikis resistance [ 14].
Evidence from mammalian models indicates that gene body methylation may have other molecular functions, such as promoting RNA polymerase pausing [ 21], modulating other epigenetic marks [ 25, 26], or affecting altering promoter usage [ 26].
According to other proposed molecular functions, circRNAs may also serve as sponges for RNA-binding proteins (RBPs), provide platforms for assembly of RBPs, and associate with mRNAs and modulate their expression post-transcriptionally [ 12].
