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Moreover, it has been possible to modulate membrane pore size obtaining a very long continued release of curcumin that maintained more than 90% of native antioxidant activity.
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The concept of ssDNA modulating an electronic signal while moving through a membrane pore led eventually to practical nanopore sequencing.
Considering that the most important event of pyroptosis is membrane pore formation, we analyzed whether DHA can cause the establishment of pores in breast cancer cell membranes.
Here, we analyzed the membrane integrity by investigating the membrane pore formation in breast cancer cells treat with DHA.
Sborgi L, et al. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
- DHA triggered membrane pore formation in breast cancer cells MDA-MB-231 and 4T1.
–DHA induced membrane pore formation dependent on caspase-1 activation, lysosomal damage and ROS formation.
Rühl, S. & Broz, P. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
We took the help of molecular dynamics simulation to understand the membrane pore forming phenomena9,10,24,25.
Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore.
It is required to build and maintain membrane, modulate membrane fluidity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com