Sentence examples for modulate malignant cell from inspiring English sources

It has been suggested that hADs could belong to tumour substrates that modulate malignant cell growth and enhance immune escape in tumours [ 12- 14].

TGF-β1 is frequently detected in squamous cell carcinomas (Eisma et al, 1996; Akhurst and Balmain, 1999) and it is likely that, independently of tumour cell responses to classical TGF-β1 signalling, the presence of LAP in the tumour stroma may modulate malignant cell behaviour through its interaction with integrins.

These molecules regulate the way in which cells perceive their environment by interacting with growth factors, enzymes, chemokines, and matrix proteins at the interface of the cell and extra cellular matrix so as to modulate signal transduction and thereby regulate malignant cell growth.

It has been theorized that the paracrine signals produced by surrounding stromal cells plays a crucial role in modulating malignant epithelial cells progression [ 18, 19].

These factors can act in concert to modulate normal and malignant cell proliferation, malignant cell migration and invasion and, often, mediate bone cancer pain.

It is conceivable that IL8 secreted by the BM and ECs under the stimulation of CML exosomes may modulate both myeloid malignant cells and the BM cellular compartment, thus generating a paracrine loop between hematopoietic malignant cells and resident cells.

Molecular targeted agents that specifically modulate inherent abnormalities in malignant cells have opened new treatment possibilities.

Peinado et al. have recently shown that cancer-derived exosomes modulate the crosstalk between malignant cells and the bone marrow (BM) microenvironment.

For example, it was recently shown that this important, yet not fully understood, effect can be evoked by both nuclear (123/125IUDR) and mostly extra-nuclear (123I]MIBG) localized Auger electron emitters, modulating cytotoxicity of neighbor malignant cells [9, 21, 22].

Malignant cell growth in his brain – a tumour.

Malignant cell growth in his brain a tumor.