Sentence examples for modulate mTORC1 activity from inspiring English sources

Moreover, E2F1 could modulate mTORC1 activity through the modulation of PLD.

Moreover, Pim-2 could modulate mTORC1 activity by directly phosphorylating TSC2 on Ser-1798 and relieves the suppression of TSC2 on mTORC1 [ 19].

To mediate these functions, the p53 protein must be activated by posttranslational modifications, which modulate p53 activity and interactions.

G1 cyclin Cln1/2 is shown to modulate Ste20 activity of MAPK pathway for a function independent of transcriptional activation of FLO11 [43].

Cholesterol binding appears to modulate CD81 activity in cells, suggesting a potential mechanism for regulation of tetraspanin function.

In vivo pharmacological effects have been used as indirect proxies for AM-1241 biotransformation processes that could modulate CB2 activity.

Many naturally occurring, molecular toxins modulate PP1 activity, though the exact mechanism of this differential regulation is not understood.

Hence, Ca2+ appears to be a crucial factor for the regulation of TRPA1 activity, suggesting that other TRP channels and GPCRs could modulate TRPA1 activity by mobilizing iCa2+.

The accessory proteins eIF4G, eIF4B, and eIF4H enhance the duplex unwinding activity of eIF4A, but the extent to which they modulate eIF4A activity is poorly understood.

There are multiple mechanisms through which ATM can modulate p53 activity.

There is growing interest in developing new drugs that modulate Hsp90 activity.