Sentence examples for modulate lysosomal functions from inspiring English sources

Overall, these data demonstrate that phenothiazines can modulate lysosomal functions in human LC cells.

Overall, these data demonstrate that phenothiazines can modulate lysosomal functions in human LC cells, as the amount of endogenous LC3-II is correlated with autophagic vesicle formation and conversion of LC3-I into LC3-II is a hallmark of autophagic activity, and changes in these processes were observed upon phenothiazine treatment especially in SCLC.

Growing evidence indicates that lysosome positioning in cells can modulate lysosomal function.

For instance, chimeric proteins bearing this sequence could be potentially used for delivering bioactive components to the endo-lysosomal compartment to modulate lysosomal function, which has broad implications for cell viability, both in carcinogenesis and degenerative processes.

We postulated that TFEB uses the v-ATPase/mTORC1 sensing device on the lysosomal surface to modulate lysosomal function according to cellular needs.

Previous studies also suggested that PGRN is involved in modulating lysosomal function.

Similar temporal patterns were seen for 5-HETE, which is rapidly produced upon inflammatory insult; 5-HETE is a potent mediator of neutrophil function, with chemotactic activity and the ability to modulate lysosomal enzyme release (Spanbroek et al. 2000).

Combined with the ability to modulate lysosomal pH during phagocytosis and maturation, murine DCs enhance their production of class II MHC-peptide complexes for presentation to T cells.

We next investigated possible mechanisms whereby CRYBA1 could modulate lysosomal V-ATPase in RPE cells.

Since the increase of lysosomal pH normally compromises the lysosomal activity, we assessed whether vacuolin-1 affects the general lysosomal functions to inhibit autophagy maturation.

Thus, impairment of lysosomal functions due to loss of lysosomal cathepsins and LAMP2, and knock-in of CLN3 facilitates autophagosome formation, resulting in lysosomal storage disorder.