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Because SCRIB and Dlgh1 were proposed to modulate lymphocyte proliferation [7], [8], [9], [10], we evaluated whether PALS1 might also participate to T cell activation.
In addition to its established role in polarity, Dlgh1 was shown to modulate lymphocyte proliferation upon T-cell receptor ligation, possibly through p38 recruitment or via the transcription factor NF-AT [9], [10], [17], [18].
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APOE is implicated in psoriasis by providing protection against some infections, as well as by modulating mitogen-activated T lymphocyte proliferation [ 33– 33].
Meanwhile, hydroquinone seems to modulate immune responses, since it inhibits lymphocyte proliferation by suppression of DNA synthesis [ 50] and exerts a cytotoxic effect in neutrophils, eosinophils, and lymphocytes via caspase 9/3 pathway [ 17, 19].
Confirming the safety levels of all the fractions by acute toxicity study in mice, they were further analysed for immune modulating potential by studying the effect on Con A and LPS induced murine lymphocyte proliferation (MTT assay).
Lymphocyte proliferation is marked by characteristic signatures of activation marker expression which eventually modulate the course of the T cell effector response.
Our in vitro data confirmed other studies [ 43] that demonstrated that catecholamines and adrenergic agonists can modulate various aspects of the immune response (initial, proliferative and effector phases), altering such functions as cytokine production, lymphocyte proliferation and antibody secretion.
Lymphocyte proliferation assay.
Reduced lymphocyte proliferation capacity was observed in CMZ-treated mice.
Lymphocyte proliferation remained unchanged in the male and female mice.
Treatment with PLGA particles alone did not inhibit lymphocyte proliferation.
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